Thermo Fisher Scientific BCR Polyclonal Antibody
Thermo Fisher Scientific의 BCR Polyclonal Antibody는 인간 BCR 단백질을 인식하는 토끼 IgG 폴리클론 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관이 가능합니다.
- 카탈로그번호
- PA529334
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 907–1231 of Human Bcr |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546810 |
Product Specific Information
- Recommended positive controls: Molt-4
- Predicted reactivity: Mouse (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, commonly found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. This translocation produces a BCR-ABL fusion protein encoded by sequences from both BCR and ABL genes. While the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product remains unclear. The BCR protein has serine/threonine kinase activity and acts as a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been identified for this gene.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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