Thermo Fisher Scientific UCP4 Polyclonal Antibody
Rabbit polyclonal antibody against human UCP4 (SLC25A27). Validated for ICC/IF applications. Supplied as a liquid, unconjugated form at 0.1 mg/mL. Affinity purified and stored in PBS with 40% glycerol. For research use only.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC25A27. Recombinant protein control fragment (Product #RP-107708) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791971 |
Product Specific Information
Immunogen sequence:
MQGEAALARL GDGARESAPY RGMVRTALGI IEEEGFL
Target Information
UCP4 is a 323 amino acid mitochondrial uncoupling protein belonging to the large mitochondrial substrate carrier family with three Solcar repeats.
It functions as a mitochondrial transport carrier that facilitates the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner membrane.
This process reduces mitochondrial membrane potential and contributes to thermoregulatory heat production by creating proton leaks across the inner mitochondrial membrane, uncoupling oxidative phosphorylation from ATP synthesis.
UCP4 is primarily expressed in adult and fetal brain, with low levels in spinal cord, corpus callosum, and substantia nigra.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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