Thermo Fisher Scientific CD49d (Integrin alpha 4) Chimeric Recombinant Mouse Monoclonal Antibody (21.6)
인간 CD49d(Integrin alpha 4)를 인식하는 키메라 재조합 마우스 단클론 항체. ELISA 및 억제 분석에 적합하며, HEK293 세포 발현 시스템에서 생산됨. Protein A로 정제된 액상 형태로 제공되며, 장기 보관 시 -20°C에서 보관 권장.
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Applications
ELISA (ELISA)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 21.6 |
| Immunogen | Alpha-4 integrin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074471 |
Product Specific Information
Specificity: This antibody binds to human alpha-4-integrin.
Target Information
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chain. The alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 are located on the alpha4 chain. These ligands include Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently, it was also demonstrated that the HIV-1 envelope can mimic Madcam by binding to and signaling through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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