Thermo Fisher Scientific TCIRG1 Polyclonal Antibody
TCIRG1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat에 반응하며 고순도 Affinity Chromatography 정제. 안정적인 PBS/glycerol buffer에 저장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–130 of human TCIRG1 (NP_0060102) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.22 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806068 |
Product Specific Information
- Immunogen sequence: MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE LEKTFTFLQE EVRRAGLVLP PPKGRLPAPP PRDLLRIQEE TERLAQELRD VRGNQQALRA QLHQLQLHAA
- Positive Samples: U2OS, A-549, BxPC-3, U-937, HL-60, Mouse thymus, Mouse skeletal muscle, Rat thymus, Rat skeletal muscle
- Cellular Location: Membrane, Multi-pass membrane protein
Target Information
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in luminal acidification of these organelles.
Genetic defects in TCIRG1 cause severe autosomal recessive osteopetrosis, characterized by increased bone density, decreased bone strength, and bone tissue inflammation.
TCIRG1 is also involved in normal insulin secretion and macrophage-mediated bacterial killing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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