Thermo Fisher Scientific SIGIRR Polyclonal Antibody
Human SIGIRR 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며, 비결합형 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Thermo Fisher Scientific SIGIRR Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides corresponding to aa 309–323 and 380–393 of human SIGIRR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2189024 |
Product Specific Information
PA1-29825 detects SIGIRR from human samples.
Target Information
SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both.
SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI.
A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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