Thermo Fisher Scientific NEDD4 Polyclonal Antibody
Rabbit polyclonal antibody against human NEDD4, validated for Western blot. Recognizes horse, human, mouse, rat, and primate species. Supplied as a liquid, purified by Protein A, and stored at -20°C. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 4–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Horse, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 200–260 of human NEDD4 was used as the immunogen. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540962 |
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the degradation of VEGFR-2/KDFR independently of its ubiquitin-ligase activity. NEDD4 acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, similar to Mdm2 and p53. It also participates in viral budding and regulates epithelial Na⁺ channels, contributing to arterial hypertension. NEDD4 is localized to the sarcolemmal region of muscle fibers, and increased expression is associated with muscle unloading and denervation, as well as decreased Notch1 expression, acting as a down-regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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