Thermo Fisher Scientific Fibronectin Recombinant Rabbit Monoclonal Antibody (23GB1335)

Applications and Tested Dilution

Product Specifications

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble protein cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling, and also present as a soluble plasma protein.

Fibronectin is composed of repeating modules forming domains that interact with other fibronectin molecules, matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins). It plays key roles in cell adhesion and migration processes such as embryogenesis, wound healing, blood coagulation, host defense, and metastasis.

Fibronectin expression is elevated in non-small cell lung carcinoma, where its interaction with cancer cells enhances tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents. The gene encoding Fibronectin undergoes alternative splicing, potentially producing up to 20 transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.