Thermo Fisher Scientific NEFM Monoclonal Antibody (OTI5H4), TrueMAB
인간 NEFM 단백질(aa 413-773)을 면역원으로 제작된 마우스 단클론 항체. Western blot에 적합하며, 신경세포 내 중간섬유 단백질 연구에 활용. 동결건조 형태로 제공되며 PBS(8% 트레할로스) 완충액에 용해 가능. 연구용으로만 사용.
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Applications
Tested Application
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5H4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 413–773 of human NEFM produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Neurofilaments (NFs) are intermediate filaments expressed almost exclusively in neuronal cells, particularly in large axons. They are composed of three subunits: neurofilament medium (NF-M), high (NF-H), and light (NF-L) proteins.
These subunits share a coiled-coil core domain but differ in terminal sequences, influencing cytoskeletal architecture and axon size.
NF-M phosphorylation and O-GlcNAcylation regulate filament formation and function.
Antibodies against neurofilament subunits serve as valuable neuronal markers due to their high abundance, neuron-specific expression, and biochemical stability.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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