ELK Biotechnology PEG3 rabbit pAb
PEG3 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC 실험에 적합합니다. 인간, 생쥐, 랫트에 반응하며 핵과 세포질에 위치한 PEG3를 검출합니다. 세포 증식 및 종양 억제 관련 연구에 활용 가능합니다.
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제품명
PEG3 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
PEG3 단백질을 인식하는 토끼 폴리클로날 항체로, 인간, 생쥐, 랫트에서 반응합니다. 세포 내 핵과 세포질에 존재하는 PEG3 단백질 검출에 사용됩니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product Name | PEG3 rabbit pAb |
| Alternative Names | PEG3; KIAA0287; ZSCAN24; Paternally-expressed gene 3 protein; Zinc finger and SCAN domain-containing protein 24 |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PEG3. AA range: 1031–1080 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 181 kDa |
| GeneID (Human) | 5178 |
| Human Swiss-Prot No | Q9GZU2 |
| Cellular Localization | Nucleus, Cytoplasm |
| Species Reactivity | Human; Rat; Mouse |
Background
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5 exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3.
In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons.
Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
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