ELK Biotechnology PDGFR-β rabbit pAb
PDGFR-β 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 세포막 및 세포질 소기관에 위치한 PDGFR-β 검출에 적합. -20°C에서 1년 보관 가능.
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ELK Biotechnology PDGFR-β rabbit pAb
제품 설명
PDGFR-β rabbit pAb는 혈소판 유래 성장 인자 수용체 베타(Platelet-derived growth factor receptor beta, PDGFR-β)를 인식하는 폴리클로날 항체입니다. 본 항체는 인간 PDGFR-β에서 유래한 합성 펩타이드(AA 991–1040)에 대해 생성되었으며, 다양한 종(인간, 마우스, 랫트)에 반응합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | PDGFR-β rabbit pAb |
| Alternative Names | PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 (Other applications not yet tested) |
| Immunogen | Synthesized peptide derived from human PDGFR beta (AA range: 991–1040) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 135–180 kDa |
| Gene ID (Human) | 5159 |
| Human Swiss-Prot No. | P09619 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cytoplasmic vesicle; Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. |
| Storage | -20°C, 1 year |
| Host | Rabbit |
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors act as mitogens for cells of mesenchymal origin. The receptor can form homodimers or heterodimers depending on the ligand bound. The gene is located on chromosome 5 near GM-CSF and M-CSF receptor genes, which may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12 that fuses this gene with ETV6 can result in chronic myeloproliferative disorder with eosinophilia. (RefSeq, Jul 2008)
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