ELK Biotechnology PDGFR-β (phospho Tyr740) rabbit pAb
PDGFR-β (phospho Tyr740) rabbit polyclonal antibody로, 인산화된 PDGFR-β 단백질 검출에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 인간·마우스·랫트 시료에 반응합니다. 세포막 및 세포소기관 내 PDGFR-β의 발현 연구에 유용합니다.
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PDGFR-β (phospho Tyr740) Rabbit pAb
제품 개요
PDGFR-β (phospho Tyr740) rabbit polyclonal antibody는 인산화된 PDGFR-β 단백질을 특이적으로 인식하도록 제작되었습니다. 세포막 및 세포 내 PDGFR-β의 발현 및 활성화 상태를 분석하는 데 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PDGFR-β (phospho Tyr740) rabbit pAb |
| Alternative Names | PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PDGFR beta around the phosphorylation site of Tyr740 (AA range: 711–760) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 135–180 kDa |
| Gene ID (Human) | 5159 |
| Human Swiss-Prot No. | P09619 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cytoplasmic vesicle; Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family, which are mitogens for cells of mesenchymal origin. The specific ligand bound determines whether the receptor forms a homodimer or heterodimer with PDGFR-α or PDGFR-β subunits. The gene is located on chromosome 5, near genes for GM-CSF and M-CSF receptor, and may be implicated in 5q syndrome. A translocation between chromosomes 5 and 12, fusing this gene with ETV6, is associated with chronic myeloproliferative disorder with eosinophilia (RefSeq, Jul 2008).
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