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ELK Biotechnology PIASy rabbit pAb
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PIASy 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인체 PIAS4 유래 펩타이드로 면역화됨. 핵 내 PML body에 주로 위치하며, SUMO화 관련 연구에 적합. -20°C에서 1년 보관 가능.
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ELK Biotechnology ES6540-100UL PIASy rabbit pAb, 100UL pk판매 단위 pk ·
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ELK Biotechnology ES6540-50UL PIASy rabbit pAb, 50UL pk판매 단위 pk ·
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ELK Biotechnology · ELK Biotechnology PIASy rabbit pAb
PIASy rabbit pAb
제품 개요
PIASy 단백질(PIAS4)을 인식하는 토끼 폴리클로날 항체입니다. 다양한 응용 분야(WB, IHC, IF, ELISA)에 활용할 수 있으며, 인체 유래 합성 펩타이드로부터 제작되었습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PIASy rabbit pAb |
| Alternative Names | PIAS4; PIASG; E3 SUMO-protein ligase PIAS4; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PIAS4 (AA range: 451–500) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kDa |
| Gene ID (Human) | 51588 |
| Human Swiss-Prot No | Q8N2W9 |
| Cellular Localization | Nucleus, PML body. Colocalizes with SUMO1, TCF7L2/TCF4, and LEF1 in a subset of PML nuclear bodies. |
| Species Reactivity | Human; Mouse |
Background
- Domain: The LXXLL motif is a coregulator signature essential for transcriptional corepression.
- Function: Acts as an E3-type SUMO ligase, stabilizing interactions between UBE2I and substrates, and serves as a SUMO-tethering factor. Plays a key role in transcriptional coregulation in pathways such as STAT, p53, Wnt, and steroid hormone signaling. Promotes PARK7 sumoylation.
- Pathway: Protein modification; protein sumoylation.
- PTM: Sumoylated at Lys-35, required for TCF4 sumoylation and transcriptional activation. Represses LEF1 transcriptional activity. SUMO1 is the preferred conjugate.
- Similarity: Belongs to the PIAS family; contains one SAP domain and one SP-RING-type zinc finger.
- Subunit: Interacts with AR, GATA2, LEF1, TP53, and STAT1 (IFNG-induced). Binds AT-rich DNA sequences (MARs/SARs). Interacts with TICAM1 and KLF8, leading to SUMO ligation and repression of KLF8 transcriptional activity and cell cycle progression.
- Tissue Specificity: Highly expressed in testis; lower levels in spleen, prostate, ovary, colon, and peripheral blood leukocytes.
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