ELK Biotechnology Tau (phospho Thr205) rabbit pAb
Tau 단백질 Thr205 인산화 부위를 인식하는 rabbit polyclonal antibody. Western blot과 ELISA에 적합. 인간, 생쥐, 랫트 반응성. 신경세포 축삭 및 세포막 관련 단백질 연구에 활용 가능.
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Tau (phospho Thr205) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Tau (phospho Thr205) rabbit pAb |
| Alternative Names | MAPT; MAPTL; MTBT1; TAU; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Antiserum produced against synthesized peptide derived from human Tau around the phosphorylation site of Thr205 (AA range: 491–540) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50–85 kD |
| GeneID (Human) | 4137 |
| Human Swiss-Prot No | P10636 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, cytosol; Cell membrane (peripheral membrane protein, cytoplasmic side); Cytoplasm, cytoskeleton; Cell projection (axon, dendrite); Secreted.
Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907).
Can be secreted; secretion depends on protein unfolding and is facilitated by cargo receptor TMED10, resulting in translocation from cytoplasm to ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).
Background
This gene encodes the microtubule-associated protein tau (MAPT), whose transcript undergoes complex, regulated alternative splicing, generating several mRNA species. MAPT transcripts are differentially expressed in the nervous system depending on neuronal maturation stage and neuron type.
MAPT gene mutations are associated with neurodegenerative disorders such as Alzheimer’s disease, Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
[Provided by RefSeq, Jul 2008]
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