ELK Biotechnology PAKγ (phospho Ser20) rabbit pAb
PAKγ (phospho Ser20) rabbit pAb는 인간 PAK2의 Ser20 인산화 부위를 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적용 가능하며 세포골격 재구성과 세포사멸 조절 연구에 유용합니다. Human, Mouse, Rat 반응성을 보입니다.
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제품명
PAKγ (phospho Ser20) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PAK2 around the phosphorylation site of Ser20 (AA range: 5–54) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 62 kDa |
| Gene ID (Human) | 5062 |
| Human Swiss-Prot No. | Q13177 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
- Serine/threonine-protein kinase PAK 2: Cytoplasm. MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
- PAK-2p34: Nucleus, cytoplasm (perinuclear region), membrane (lipid-anchor). Interaction with ARHGAP10 likely changes localization to the cytoplasmic perinuclear region. Myristoylation shifts localization to the membrane.
배경 (Background)
The p21 activated kinases (PAK) are critical effectors linking Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins are a family of serine/threonine kinases that serve as targets for small GTP-binding proteins CDC42 and RAC1, and are implicated in a wide range of biological activities. The gene-encoded protein is activated by proteolytic cleavage during caspase-mediated apoptosis and may play a role in regulating apoptotic events in dying cells.
[Provided by RefSeq, Jul 2008]
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