ELK Biotechnology PAKα/β/γ rabbit pAb
PAKα/β/γ rabbit polyclonal antibody로, PAK1/2/3 단백질을 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며 세포 이동성과 형태 조절 관련 연구에 적합합니다. 인간, 마우스, 랫트 시료 반응성이 있습니다.
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ELK Biotechnology PAKα/β/γ rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | PAKα/β/γ rabbit pAb |
| Alternative Names | PAK1; Serine/threonine-protein kinase PAK1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK; PAK2; Serine/threonine-protein kinase PAK2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58; PAK3; OPHN3; Serine/threonine-protein kinase PAK3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human PAK1/2/3 (AA range: 391–440) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 62 kDa |
| GeneID (Human) | 5058 / 5062 / 5063 |
| Human Swiss-Prot No. | Q13153 / Q13177 / O75914 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm, cell junction (focal adhesion), cell projection (lamellipodium, ruffle membrane, invadopodium), cell membrane, nucleus (nucleoplasm, chromosome), cytoskeleton (microtubule organizing center, centrosome).
Colocalizes with RUFY3, F-actin, and core migration components in invadopodia at the cell periphery (PubMed:25766321).
Recruited to the cell membrane via CDC42 and RAC1 interaction, and to focal adhesions upon activation.
Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin.
Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212, co-recruited with MORC2 on damaged chromatin (PubMed:23260667).
Localization to the centrosome is independent of phosphorylation state.
Background
This gene encodes a family member of serine/threonine p21-activated kinases (PAKs), which are key effectors linking Rho GTPases to cytoskeleton reorganization and nuclear signaling.
PAK proteins regulate cell motility and morphology and act as targets for small GTP-binding proteins such as Cdc42 and Rac.
Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, Apr 2010).
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