ELK Biotechnology PAKα/β/γ (phospho Ser144/141/139) rabbit pAb
PAKα/β/γ 인산화(Ser144/141/139) 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 적합하며 세포 이동 및 형태 조절 연구에 활용. 인간, 마우스, 랫트 반응성. 고순도 IgG, 1 mg/ml, -20°C 보관.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology PAKα/β/γ (phospho Ser144/141/139) rabbit pAb
제품명
PAKα/β/γ (phospho Ser144/141/139) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PAK1; Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK; PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58; PAK3; OPHN3; Serine/threonine-protein kinase PAK3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human PAK1/2/3 around phosphorylation site Ser144/141/139 (AA range: 111–160) |
| Host | Rabbit |
| Storage | -20°C for 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kDa |
| Gene ID (Human) | 5058 / 5062 / 5063 |
| Human Swiss-Prot No. | Q13153 / Q13177 / O75914 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm; Cell junction (focal adhesion); Cell projection (lamellipodium, ruffle membrane, invadopodium); Cell membrane; Nucleus (nucleoplasm, chromosome); Cytoplasm (cytoskeleton, microtubule organizing center, centrosome).
Colocalizes with RUFY3, F-actin, and other migration components in invadopodia at the cell periphery (PubMed:25766321).
Recruited to the cell membrane via CDC42 and RAC1 interaction and to focal adhesions upon activation.
Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin.
Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212, co-recruited with MORC2 on damaged chromatin (PubMed:23260667).
Localization to the centrosome does not depend on phosphorylation status.
배경 (Background)
This gene encodes a member of the serine/threonine p21-activated kinase (PAK) family. PAK proteins are key effectors linking RhoGTPases to cytoskeletal reorganization and nuclear signaling, serving as targets for small GTP-binding proteins Cdc42 and Rac.
This family member regulates cell motility and morphology.
Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, Apr 2010).
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.