ELK Biotechnology PAKα (phospho Thr212) rabbit pAb
PAKα (phospho Thr212) rabbit pAb는 인산화된 Thr212 부위를 인식하는 폴리클로날 항체로, 세포 이동성과 형태 조절 연구에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 인간, 마우스, 랫트에 반응합니다. 고순도 IgG 형태로 -20°C에서 1년간 안정 저장됩니다.
- 판매단위
- pk
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제품명
PAKα (phospho Thr212) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PAK1; Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PAK1 around the phosphorylation site of Thr212 (AA range: 178–227) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kD |
| Gene ID (Human) | 5058 |
| Human Swiss-Prot No | Q13153 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm; Cell junction; Focal adhesion; Cell projection (lamellipodium, ruffle membrane, invadopodium); Cell membrane; Nucleus (nucleoplasm, chromosome); Cytoskeleton (microtubule organizing center, centrosome).
Colocalizes with RUFY3, F-actin, and other migration components in invadopodia at the cell periphery (PubMed:25766321).
Recruited to the cell membrane via interaction with CDC42 and RAC1, and to focal adhesions upon activation.
Colocalized with CIB1 within membrane ruffles during cell spreading on fibronectin.
Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212, co-recruited with MORC2 on damaged chromatin (PubMed:23260667).
배경 (Background)
This gene encodes a member of the serine/threonine p21-activating kinase (PAK) family. PAK proteins are critical effectors linking RhoGTPases to cytoskeleton reorganization and nuclear signaling, serving as targets for small GTP-binding proteins Cdc42 and Rac. This family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, Apr 2010).
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