ELK Biotechnology Claudin-11 rabbit pAb
Claudin-11 단백질을 인식하는 토끼 다클론 항체로, WB와 ELISA에 적합합니다. 인간, 마우스, 랫에서 반응하며, 세포막의 타이트 정션 단백질 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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Claudin-11 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Claudin-11 rabbit pAb |
| Alternative Names | CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range: 158-207 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20 kD |
| GeneID (Human) | 5010 |
| Human Swiss-Prot No | O75508 |
| Cellular Localization | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.
The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been described.
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