ELK Biotechnology KOR-1 rabbit pAb
KOR-1 rabbit pAb는 인간 OPRK1 유래 펩타이드로 제작된 폴리클로날 항체로, WB, ELISA, IHC에 적합합니다. 세포막에 위치한 Kappa-type opioid receptor를 인식하며, 통증 및 오피오이드 반응 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
KOR-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human OPRK1 (AA range: 321–370). |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| Gene ID (Human) | 4986 |
| Human Swiss-Prot No. | P41145 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands as well as various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This receptor plays a role in pain perception and mediates the hypolocomotor, analgesic, and aversive actions of synthetic opioids. Variations in this gene have been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found. A recent study provided evidence for translational readthrough and expression of an additional C-terminally extended isoform via an alternative in-frame translation termination codon (RefSeq, Jan 2016).
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