
ELK Biotechnology AZ1 rabbit pAb
OAZ1 단백질을 인식하는 고품질 rabbit polyclonal antibody로, WB, IHC, IF, ELISA 등에 사용 가능. 인간, 마우스, 랫트 반응성 보유. 세포 성장 조절 관련 연구에 적합하며, -20°C에서 1년간 안정적으로 보관 가능.
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제품명
AZ1 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
OAZ1 (Ornithine decarboxylase antizyme 1)을 인식하는 rabbit polyclonal antibody입니다. 세포 성장 및 증식 조절에 관련된 연구에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | OAZ1; OAZ; Ornithine decarboxylase antizyme 1; ODC-Az |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300 ELISA: 1/40000 WB: 1/500–1/2000 |
| Immunogen | Synthesized peptide derived from human OAZ1 (AA range: 14–63) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4946 |
| Human Swiss-Prot No. | P54368 |
| Cellular Localization | Nucleus, cytoplasm, cytosol |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which regulates cell growth and proliferation by controlling intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, enhanced by high polyamine levels. Antizyme 1 binds and inhibits ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, completing an auto-regulatory circuit. It negatively regulates intracellular polyamine levels by targeting ODC for degradation and inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of these sites results in N-terminally distinct isoforms.
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