ELK Biotechnology Trk A rabbit pAb
Trk A rabbit pAb는 인간, 랫트, 마우스에 반응하는 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능. 인간 Trk A 유래 펩타이드(AA 747-796)를 면역원으로 제작. 고감도 신경성 성장 인자 수용체 검출에 적합하며, -20°C에서 1년 보관 가능.
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제품명
Trk A rabbit pAb
공급업체
ELK Biotechnology
제품 설명
Trk A rabbit pAb는 인간 Trk A 단백질을 인식하는 폴리클로날 항체로, 신경 성장 인자 수용체(NTRK1)의 발현을 검출하는 데 사용됩니다. IHC, IF, ELISA 분석에 적용 가능하며, 세포막 및 엔도좀 내 단백질 위치 연구에 유용합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Trk A (AA range: 747–796) |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 140–180 kD |
| GeneID (Human) | 4914 |
| Human Swiss-Prot No | P04629 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Early, late, and recycling endosome membranes. Rapidly internalized after NGF binding and transported via retrograde axonal transport. Localized at cell membrane and early endosomes before NGF stimulation; recruited to late endosomes after NGF stimulation; colocalized with RAPGEF2 at late endosomes. |
Background
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. It plays a role in cell differentiation and sensory neuron subtype specification. Mutations are associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer. Alternate transcriptional splice variants exist, with three characterized to date. (RefSeq, Jul 2008)
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