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ELK Biotechnology Trk A (phospho Tyr496) rabbit pAb
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Trk A (phospho Tyr496) rabbit polyclonal antibody로, 인간, 생쥐, 랫트 시료에 반응합니다. WB, IF, ELISA에 사용 가능하며 Tyr496 인산화 부위에 특이적입니다. 고품질 IgG 형식으로 -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
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ELK Biotechnology ES6425-100UL Trk A (phospho Tyr496) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES6425-50UL Trk A (phospho Tyr496) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Trk A (phospho Tyr496) rabbit pAb
제품명
Trk A (phospho Tyr496) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Trk A around the phosphorylation site of Tyr496 (AA range: 471–520) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 140–180 kD |
| GeneID (Human) | 4914 |
| Human Swiss-Prot No | P04629 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Late endosome membrane; Recycling endosome membrane. Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon NGF or NTF3 binding and transported to the cell body via retrograde axonal transport. Localized at cell membrane and early endosomes before NGF stimulation; recruited to late endosomes after NGF stimulation; colocalized with RAPGEF2 at late endosomes. |
| Background | This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. (RefSeq, Jul 2008) |
| Species Reactivity | Human; Mouse; Rat |
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