ELK Biotechnology YB-1 rabbit pAb
인간 YBX1 단백질을 인식하는 ELK Biotechnology의 YB-1 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. 세포 내 핵 및 세포질에서 발현되는 단백질 검출에 적합하며, 암 관련 연구 및 단백질 발현 분석에 유용.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology YB-1 rabbit pAb
ELK Biotechnology YB-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | YB-1 rabbit pAb |
| Alternative Names | YBX1; NSEP1; YB1; Nuclease-sensitive element-binding protein 1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1; YB- |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC-p: 100-300; Western Blot: 1/500 - 1/2000; ELISA: 1/40000; Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human YBX1 (AA range: 68–117) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 36 kD |
| GeneID (Human) | 4904 |
| Human Swiss-Prot No | P67809 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm, nucleus, cytoplasmic granule, secreted, extracellular exosome. Predominantly cytoplasmic in proliferating cells (PubMed:12604611). Cytotoxic stress and DNA damage enhance translocation to the nucleus (PubMed:14718551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:25229427). Shuttles between nucleus and cytoplasm (PubMed:25229427). Localized with DDX1, MBNL1, and TIAL1 in stress granules upon stress (PubMed:18335541). Secreted by mesangial and monocytic cells after inflammatory challenges (PubMed:19483673).
배경 (Background)
This gene encodes a highly conserved cold shock domain protein with broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and is involved in transcription and translation regulation, pre-mRNA splicing, DNA repair, and mRNA packaging. It is a component of messenger ribonucleoprotein (mRNP) complexes and may play a role in microRNA processing. The protein can be secreted through non-classical pathways and acts as an extracellular mitogen. Aberrant expression is associated with cancer proliferation and may serve as a prognostic marker for poor outcomes and drug resistance. Alternate splicing results in multiple transcript variants. Pseudogenes are found on multiple chromosomes. [RefSeq, Sep 2015]
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.