ELK Biotechnology Nephrin rabbit pAb
Nephrin 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA 등에 사용 가능. 인간 Nephrin 유래 펩타이드로 면역화되었으며, 신장 사구체 여과 장벽 연구에 적합. -20°C에서 1년 보관 가능.
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ELK Biotechnology Nephrin rabbit pAb
제품 개요
Nephrin rabbit pAb는 인간 Nephrin 단백질을 인식하는 토끼 폴리클로날 항체로, 신장 사구체 여과 장벽 및 podocyte 관련 연구에 유용합니다. 다양한 응용 분야(WB, IHC, IF, ELISA)에 사용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Nephrin rabbit pAb |
| Alternative Names | NPHS1; NPHN; Nephrin; Renal glomerulus-specific cell adhesion receptor |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Nephrin (AA range: 843–892) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4868 |
| Human Swiss-Prot No | O60500 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane. |
Background
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm functions as an ultrafilter to exclude albumin and other plasma macromolecules during urine formation. Mutations in this gene cause Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
[provided by RefSeq, Oct 2009]
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