ELK Biotechnology NFκB-p100 (phospho Ser869) rabbit pAb

제품명

NFκB-p100 (phospho Ser869) rabbit pAb

대체 명칭

NFKB2; LYT10; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10

적용 분야 (Applications)

WB, IHC, IF, IP, ELISA

권장 희석 배수 (Recommended Dilutions)

• Western Blot: 1/500 - 1/2000
• Immunohistochemistry: 1/100 - 1/300
• Immunoprecipitation: 2–5 µg/mg lysate
• ELISA: 1/10000
• Other applications: Not yet tested

면역원 (Immunogen)

Synthesized peptide derived from human NF-κB p100/p52 around the phosphorylation site of Ser869 (AA range: 836–885)

보관 (Storage)

• Host: Rabbit
• Storage condition: -20°C / 1 year

항체 특성 (Antibody Properties)

배경 (Background)

Nuclear factor kappa B subunit 2 (NFKB2) is a component of the NF-κB transcription factor complex, which regulates genes involved in inflammation and immune function. The encoded protein can act as both a transcriptional activator and repressor depending on its dimerization partner. The full-length p100 protein is co-translationally processed into the active p52 form. Chromosomal rearrangements and translocations of this locus are associated with certain B-cell lymphomas, potentially leading to fusion protein formation. A pseudogene exists on chromosome 18, and alternative splicing produces multiple transcript variants. (RefSeq, Dec 2013)