ELK Biotechnology NFATc4 (phospho Ser168/S170) rabbit pAb
NFATc4 단백질의 Ser168/Ser170 인산화 부위를 인식하는 rabbit polyclonal 항체로, WB, IHC, IF, ELISA에 적합. 세포 내 NFAT 신호전달 연구 및 인산화 상태 분석에 활용 가능. Human 및 Mouse 시료 반응성 확인.
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제품명
NFATc4 (phospho Ser168/S170) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NFATC4; NFAT3; Nuclear factor of activated T-cells, cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human NFAT3 around the phosphorylation site of Ser168 and Ser170 (AA range: 136–185) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 140 kDa |
| GeneID (Human) | 4776 |
| Human Swiss-Prot No | Q14934 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cytoplasm, cytosol, and nucleus. When hyperphosphorylated, localizes in the cytosol. Upon increased intracellular Ca²⁺, dephosphorylation by calcineurin (PPP3CA) induces nuclear translocation (PubMed:11997522, 18347059). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export via phosphorylation at Ser-168 and Ser-170 (PubMed:18347059). |
Background
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family, which forms a DNA-binding transcription complex. The complex includes a cytosolic component that translocates to the nucleus upon T-cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase calcineurin and play a key role in cytokine gene expression, particularly interleukin-2 and interleukin-4 induction. Alternative splicing results in multiple transcript variants.
[Provided by RefSeq, Jan 2014]
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