ELK Biotechnology ATP-citrate synthase (phospho Ser455) rabbit pAb
ATP-citrate synthase (phospho Ser455) rabbit polyclonal antibody for detection of phosphorylated ACLY in human, mouse, rat, and monkey samples. Suitable for WB, IHC, IF, and ELISA. High specificity and stability with 1 mg/ml concentration, stored at −2...
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ATP-citrate synthase (phospho Ser455) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ATP-Citrate Lyase around the phosphorylation site of Ser454 (AA range: 420–469) |
| Host | Rabbit |
| Storage | −20 °C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 125 kD |
| Gene ID (Human) | 47 |
| Human Swiss-Prot No | P53396 |
| Cellular Localization | Cytoplasm, cytosol |
| Species Reactivity | Human; Mouse; Rat; Monkey |
배경 (Background)
ATP citrate lyase (ACLY) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (molecular weight ~440,000) composed of identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with hydrolysis of ATP to ADP and phosphate. Acetyl-CoA serves several biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in acetylcholine biosynthesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. (RefSeq, Dec 2014)
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