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ELK Biotechnology Nibrin (phospho Ser278) rabbit pAb
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Nibrin (phospho Ser278) rabbit polyclonal antibody로, 인간 NBN 단백질의 Ser278 인산화 부위를 인식합니다. WB, IF, ELISA에 사용 가능하며, DNA 손상 반응 연구에 적합합니다. 핵 및 염색체 부위에서의 단백질 위치 연구에 활용됩니다.
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- pk
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ELK Biotechnology ES6335-100UL Nibrin (phospho Ser278) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES6335-50UL Nibrin (phospho Ser278) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Nibrin (phospho Ser278) rabbit pAb
Nibrin (phospho Ser278) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Nibrin (phospho Ser278) rabbit pAb |
| Alternative Names | NBN; NBS; NBS1; P95; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Nibrin around the phosphorylation site of Ser278 (AA range: 251–300) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 95 kDa |
| Gene ID (Human) | 4683 |
| Human Swiss-Prot No. | O60934 |
| Cellular Localization | Nucleus; PML body; Chromosome; Telomere. Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of Lys-5 of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at DNA damage sites (PubMed:26438602). |
| Background | Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex, involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [RefSeq, Jul 2008] |
| Species Reactivity | Human; Rat; Mouse |
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