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ELK Biotechnology Nibrin (phospho Ser343) rabbit pAb
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Nibrin (phospho Ser343) rabbit pAb는 인간 및 랫트 시료에서 사용 가능한 폴리클로날 항체로, DNA 손상 반응 관련 단백질 Nibrin의 Ser343 인산화를 검출합니다. WB와 ELISA에 적합하며, 고특이성과 안정적 보관(-20°C, 1년)이 가능합니다.
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ELK Biotechnology ES6334-100UL Nibrin (phospho Ser343) rabbit pAb, 100UL pk판매 단위 pk ·
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ELK Biotechnology ES6334-50UL Nibrin (phospho Ser343) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Nibrin (phospho Ser343) rabbit pAb
제품명
Nibrin (phospho Ser343) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NBN; NBS; NBS1; P95; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human p95/NBS1 around the phosphorylation site of Ser343. AA range: 310-359 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 95 kD |
| GeneID (Human) | 4683 |
| Human Swiss-Prot No | O60934 |
| Cellular Localization | Nucleus; PML body; Chromosome; Telomere. Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of Lys-5 of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602). |
| Background | Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008] |
| Species Reactivity | Human; Rat |
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