ELK Biotechnology ATF-1 rabbit pAb
ATF-1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 및 마우스 시료에 반응하며, 세포 핵에서 발현되는 ATF1 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
ATF-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ATF1; Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; Protein TREB36 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ATF1 (AA range: 31–80) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 29 kDa |
| Gene ID (Human) | 466 |
| Human Swiss-Prot No. | P18846 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
Activating transcription factor 1 (ATF1) is a member of the ATF subfamily and the bZIP (basic-region leucine zipper) family. It regulates the expression of downstream target genes involved in growth, survival, and other cellular activities. The protein is phosphorylated at serine 63 by several kinases, including cAMP-dependent protein kinase A, calmodulin-dependent kinase I/II, mitogen- and stress-activated protein kinase, and cyclin-dependent kinase 3 (cdk-3). Phosphorylation enhances its transactivation and transcriptional activities, promoting cell transformation. Chromosomal translocations involving ATF1 and FUS (chromosome 16) or EWSR1 (chromosome 22) generate chimeric proteins implicated in angiomatoid fibrous histiocytoma and clear cell sarcoma. A pseudogene also exists on another chromosome.
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