ELK Biotechnology ATF-1 (phospho Ser63) rabbit pAb
ATF-1 (phospho Ser63) rabbit polyclonal antibody로, 인산화된 Ser63 부위를 인식합니다. Western blot 및 ELISA에 적합하며, 인간 및 생쥐 시료에서 반응합니다. 세포 성장 및 생존 관련 유전자 발현 연구에 활용 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology ATF-1 (phospho Ser63) rabbit pAb
ATF-1 (phospho Ser63) Rabbit Polyclonal Antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ATF-1 (phospho Ser63) rabbit pAb |
| Alternative Names | ATF1; Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; Protein TREB36 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ATF1 around the phosphorylation site of Ser63 (AA range: 31-80) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 29 kDa |
| Gene ID (Human) | 466 |
| Human Swiss-Prot No. | P18846 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
Activating transcription factor 1 (ATF1) is a member of the ATF subfamily and the bZIP (basic-region leucine zipper) family. It regulates downstream target gene expression involved in cell growth, survival, and other physiological processes.
ATF1 is phosphorylated at serine 63 by several kinases, including cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase, and cyclin-dependent kinase 3 (cdk-3).
Phosphorylation enhances its transactivation and transcriptional activities, promoting cell transformation.
Chromosomal translocations involving ATF1 and FUS (chromosome 16) or EWSR1 (chromosome 22) produce chimeric proteins implicated in angiomatoid fibrous histiocytoma and clear cell sarcoma.
This gene also has a pseudogene on another chromosome.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.