ELK Biotechnology Myosin IXb rabbit pAb
Myosin IXb 단백질을 인식하는 토끼 폴리클로날 항체로, WB, ELISA, IHC에 적합합니다. 인간 MYO9B 유래 펩타이드로 면역화되었으며, 세포질 및 세포골격에 주로 발현됩니다. 셀리악병 및 궤양성 대장염 관련 연구에 활용 가능합니다.
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제품 개요
Myosin IXb rabbit pAb는 인간 MYO9B 단백질에 특이적인 토끼 폴리클로날 항체입니다. 이 항체는 비정상적 미오신 계열 단백질을 인식하며, 세포질 및 세포골격 내에서 발현 양상을 연구하는 데 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Myosin IXb rabbit pAb |
| Alternative Names | MYO9B; MYR5; Unconventional myosin-IXb; Unconventional myosin-9b |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized peptide derived from human MYO9B (AA range: 304–353) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 250 kDa |
| Gene ID (Human) | 4650 |
| Human Swiss-Prot No. | Q13459 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, cell cortex, perinuclear region, cytoskeleton. In undifferentiated cells, colocalizes with F-actin at the cell periphery; in differentiated cells, mainly cytoplasmic with highest levels in the perinuclear region. |
Background
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin, distinct from the conventional non-muscle myosin-9 (MYH9). It contains four IQ motifs in the neck domain that bind calmodulin as a light chain. The complex has a single-headed structure and moves processively along actin filaments toward the minus end. It also possesses rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been identified (RefSeq, Dec 2011).
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