ELK Biotechnology c-Myc (phospho Thr358) rabbit pAb
c-Myc (phospho Thr358) rabbit polyclonal antibody로 세포 내 Myc 단백질의 Thr358 인산화 상태를 검출. IHC, IF, IP, ELISA에 적합. 인간, 마우스, 랫트 반응성. 핵 내 위치 단백질 분석에 유용. -20°C에서 1년 보관 가능.
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ELK Biotechnology c-Myc (phospho Thr358) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | c-Myc (phospho Thr358) rabbit pAb |
| Alternative Names | MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 |
| Applications | IHC; IF; IP; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 Immunoprecipitation: 2–5 µg/mg lysate ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Thr358. AA range: 325–374 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kDa (also ~60 kDa in some samples) |
| GeneID (Human) | 4609 |
| Human Swiss-Prot No | P01106 |
| Cellular Localization | Nucleus, nucleoplasm; Nucleus, nucleolus |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a multifunctional nuclear phosphoprotein involved in cell cycle progression, apoptosis, and cellular transformation. It functions as a transcription factor regulating specific target genes. Mutations, overexpression, rearrangement, and translocation of this gene are associated with various hematopoietic tumors, leukemias, and lymphomas, including Burkitt lymphoma. Alternative translation initiation from upstream non-AUG (CUG) and downstream AUG sites produces two isoforms with distinct N-termini. The non-AUG initiated form is suppressed in Burkitt’s lymphomas, indicating its functional importance.
[provided by RefSeq, Jul 2008]
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