ELK Biotechnology AF-4 rabbit pAb
AF-4 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, IF, WB, ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며, RNA 중합효소 II 매개 전사 조절 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology AF-4 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | AF-4 rabbit pAb |
| Alternative Names | AFF1; AF4; FEL; MLLT2; PBM1; AF4/FMR2 family member 1; ALL1-fused gene from chromosome 4 protein; Protein AF-4; Protein FEL; Proto-oncogene AF4 |
| Applications | IHC; IF; WB; ELISA |
| Recommended Dilutions | WB: 1:500–1:2000 Immunohistochemistry: 1:100–1:300 ELISA: 1:20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AF4 (AA range: 1–50) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kDa |
| Gene ID (Human) | 4299 |
| Human Swiss-Prot No | P51825 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a member of the AF4/lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
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