ELK Biotechnology MITF (phospho Ser180) rabbit pAb
MITF (phospho Ser180) rabbit polyclonal antibody로, 인간, 마우스, 원숭이에 반응합니다. WB, IHC, IF, ELISA에 적합하며, 핵 내 인산화된 MITF 단백질 검출에 사용됩니다. 멜라노사이트 분화 및 색소 형성 연구에 유용합니다.
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MITF (phospho Ser180) rabbit pAb
제품 개요
ELK Biotechnology에서 제공하는 MITF (phospho Ser180) rabbit polyclonal antibody는 인산화된 MITF 단백질을 검출하기 위한 항체로, 멜라노사이트 및 색소세포 관련 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MITF (phospho Ser180) rabbit pAb |
| Alternative Names | MITF; BHLHE32; Microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; bHLHe32 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MITF around the phosphorylation site of Ser180/73. AA range: 151–200 |
| Species Reactivity | Human; Mouse; Monkey |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 52 kD |
| GeneID (Human) | 4286 |
| Human Swiss-Prot No | O75030 |
| Cellular Localization | Nucleus; Cytoplasm; Found exclusively in the nucleus upon phosphorylation |
| Storage | -20°C / 1 year |
| Host Species | Rabbit |
Background
This gene encodes a transcription factor containing both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes and retinal pigment epithelium, and controls pigment cell-specific transcription of melanogenesis enzyme genes.
Heterozygous mutations in this gene cause auditory-pigmentary syndromes such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
[provided by RefSeq, Jul 2008]
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