ELK Biotechnology ASK 1 (phospho Ser83) rabbit pAb
ASK1 (phospho Ser83) rabbit polyclonal antibody로 MAPK 신호전달 연구에 적합. WB, IHC, IF, ELISA 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 IgG, -20°C에서 1년 안정 보관.
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ASK 1 (phospho Ser83) rabbit pAb
제품 개요
ASK1 (Apoptosis signal-regulating kinase 1)는 MAPK 신호전달 경로의 상위 조절 인자로, 세포 스트레스 반응 및 아포토시스 조절에 관여합니다. 본 항체는 인간 ASK1의 Ser83 인산화 부위를 인식하도록 설계된 rabbit polyclonal antibody입니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ASK 1 (phospho Ser83) rabbit pAb |
| Alternative Names | MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ASK1 around the phosphorylation site of Ser83 (AA range: 49–98) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4217 |
| Human Swiss-Prot No | Q99683 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm; Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region. |
Background
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK (ERK), MAPK kinase (MEK), and MAPK kinase kinase (MEKK). MAPKKK/MEKK phosphorylates and activates MAPK kinase/MEK, which in turn activates MAPK.
MAPKKK5 (ASK1) contains 1,374 amino acids and includes all 11 kinase subdomains. Northern blot analysis shows high expression of MAPKKK5 transcript in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 in vitro and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells, but does not activate MAPK/ERK.
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