ELK Biotechnology MEK Kinase-4 rabbit pAb
MEK Kinase-4 rabbit pAb는 인간 MAP3K4 유래 펩타이드로 제작된 폴리클로날 항체입니다. IHC, IF, ELISA에 적합하며 세포질 및 주위핵 영역에 위치한 MEKK4 단백질을 검출합니다. -20℃에서 1년 보관 가능하며 고순도 IgG 형태로 제공됩니다.
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제품명
MEK Kinase-4 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAP3K4; KIAA0213; MAPKKK4; MEKK4; MTK1; Mitogen-activated protein kinase kinase kinase 4; MAP three kinase 1; MAPK/ERK kinase kinase 4; MEK kinase 4; MEKK 4 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MAP3K4 (AA range: 1281–1330) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4216 |
| Human Swiss-Prot No | Q9Y6R4 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cytoplasm, perinuclear region. Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. |
Background
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK.
While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors.
This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6.
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