ELK Biotechnology MEF-2D rabbit pAb
MEF-2D rabbit pAb는 인간, 마우스, 랫트에서 반응하는 다클론 항체입니다. IHC, IF, ELISA에 사용 가능하며, 근육 및 신경 세포 분화 관련 전사인자 MEF2D를 검출합니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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제품명
MEF-2D rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MEF2D; Myocyte-specific enhancer factor 2D |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MEF2D (AA range: 410-459) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 4209 |
| Human Swiss-Prot No | Q14814 |
| Cellular Localization | Nucleus; Translocated by HDAC4 to nuclear dots |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases.
Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis.
The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Oct 2012]
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