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ELK Biotechnology MDM2 (phospho Ser166) rabbit pAb
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ELK Biotechnology MDM2 (phospho Ser166) rabbit pAb

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MDM2 단백질의 Ser166 인산화 부위를 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 생쥐, 원숭이에 반응하며, 핵 및 세포질에서 발현되는 MDM2 단백질 연구에 유용합니다.

판매단위
pk
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ELK Biotechnology ES6209-100UL MDM2 (phospho Ser166) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES6209-50UL MDM2 (phospho Ser166) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology MDM2 (phospho Ser166) rabbit pAb

제품명

MDM2 (phospho Ser166) rabbit pAb

제품 정보

항목 내용
Alternative Names MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2
Applications WB; IHC; IF; ELISA
Recommended Dilutions Western Blot: 1/500 - 1/2000
Immunohistochemistry: 1/100 - 1/300
Immunofluorescence: 1/200 - 1/1000
ELISA: 1/5000
Not yet tested in other applications
Immunogen Synthesized peptide derived from human MDM2 around the phosphorylation site of Ser166 (AA range: 132–181)
Host Rabbit
Storage -20°C / 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 90 kD
Gene ID (Human) 4193
Human Swiss-Prot No. Q00987
Species Reactivity Human; Mouse; Monkey
Cellular Localization Nucleus, nucleoplasm, cytoplasm, nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in localization of both proteins to the nucleolus. Colocalizes with RASSF1 isoform A in the nucleus.
Background This gene encodes a nuclear-localized E3 ubiquitin ligase that promotes tumor formation by targeting tumor suppressor proteins such as p53 for proteasomal degradation. It is transcriptionally regulated by p53. Overexpression or amplification is found in various cancers. A pseudogene exists on chromosome 2. Alternative splicing produces multiple transcript variants, many expressed only in tumor cells. (RefSeq, Jun 2013)

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