ELK Biotechnology Lsk rabbit pAb
Lsk rabbit pAb는 인간 Lsk 단백질을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능합니다. 세포질 및 막에 위치하며, 혈액세포 신호전달 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Lsk rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MATK; CTK; HYL; Megakaryocyte-associated tyrosine-protein kinase; CSK homologous kinase; CHK; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL; Tyrosine-protein kinase CTK |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human Lsk |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| Gene ID (Human) | 4145 |
| Human Swiss-Prot No | P42679 |
| Cellular Localization | Cytoplasm, Membrane. In platelets, 90% of MATK localizes to the membrane fraction and translocates to the cytoskeleton upon thrombin stimulation. |
| Species Reactivity | Human; Mouse; Rat |
배경 (Background)
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site.
This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases and may play an inhibitory role in the control of T-cell proliferation.
This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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