ELK Biotechnology Tau (phospho Thr231) rabbit pAb
Tau 단백질의 Thr231 인산화 부위를 인식하는 토끼 폴리클로날 항체로, 인간, 마우스, 랫트 반응성. WB 및 ELISA에 적합하며, 알츠하이머병 등 신경퇴행성 질환 연구에 활용 가능. -20°C 보관.
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Tau (phospho Thr231) rabbit pAb
제품 개요
Tau 단백질의 Thr231 인산화 부위를 인식하는 토끼 폴리클로날 항체로, 미세소관 결합 단백질인 Tau의 인산화 상태를 검출하는 데 사용됩니다. 알츠하이머병 등 신경퇴행성 질환 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Tau (phospho Thr231) rabbit pAb |
| Alternative Names | MAPT; MAPTL; MTBT1; TAU; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Tau around the phosphorylation site of Thr231 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50–85 kDa |
| GeneID (Human) | 4137 |
| Human Swiss-Prot No | P10636 |
| Cellular Localization | Cytoplasm, cytosol; Cell membrane (peripheral membrane protein, cytoplasmic side); Cytoskeleton; Axon; Dendrite; Secreted. Mostly found in neuronal axons, cytosol, and plasma membrane-associated regions. Secretion is dependent on protein unfolding and facilitated by TMED10, leading to translocation into ERGIC and subsequent vesicle-mediated secretion. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes the microtubule-associated protein tau (MAPT), whose transcript undergoes complex, regulated alternative splicing, producing several mRNA species. MAPT transcripts are differentially expressed in the nervous system depending on neuronal maturation stage and neuron type. Mutations in the MAPT gene are linked to neurodegenerative disorders such as Alzheimer’s disease, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
[Provided by RefSeq, Jul 2008]
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