ELK Biotechnology Tau (phospho Ser214) rabbit pAb
Tau 단백질의 Ser214 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. WB 및 ELISA에 적합하며 인간, 생쥐, 랫트 시료에서 반응. 신경퇴행성 질환 연구에 유용. -20°C에서 1년 보관 가능.
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Tau (phospho Ser214) rabbit pAb
제품 개요
Tau 단백질의 Ser214 인산화 부위를 인식하는 rabbit polyclonal antibody로, 신경세포 내 미세소관 결합 단백질 연구에 적합합니다. Alzheimer’s disease 및 기타 신경퇴행성 질환 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Tau (phospho Ser214) rabbit pAb |
| Alternative Names | MAPT; MAPTL; MTBT1; TAU; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000; ELISA: 1/5000 (other applications not yet tested) |
| Immunogen | Synthesized peptide derived from human Tau around the phosphorylation site of Ser214 (AA range: 501–550) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50–85 kDa |
| GeneID (Human) | 4137 |
| Human Swiss-Prot No | P10636 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cytoplasm, cytosol; Cell membrane (Peripheral membrane protein, cytoplasmic side); Cytoplasm, cytoskeleton; Cell projection (axon, dendrite); Secreted.
Mostly found in neuronal axons, cytosol, and associated with plasma membrane components (PubMed:10747907).
Can be secreted via TMED10-mediated translocation to ERGIC followed by vesicle entry and secretion (PubMed:32272059).
Background
This gene encodes the microtubule-associated protein tau (MAPT), which undergoes complex alternative splicing resulting in multiple mRNA species. MAPT expression varies across neuronal types and maturation stages. Mutations in MAPT are linked to neurodegenerative disorders such as Alzheimer’s disease, Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
[Provided by RefSeq, Jul 2008]
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