ELK Biotechnology Smad2 (phospho Ser250) rabbit pAb
Smad2 단백질의 Ser250 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, ELISA, IHC에 적합하며 인산화된 Smad2 신호 전달 연구에 활용 가능. Human, Mouse, Rat 반응성. -20°C 보관 시 1년 안정.
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제품명
Smad2 (phospho Ser250) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 2000–20000 |
| Immunogen | Synthesized peptide derived from human Smad2 around the phosphorylation site of Ser250 (AA range: 216–265) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kD |
| GeneID (Human) | 4087 |
| Human Swiss-Prot No | Q15796 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Cellular Localization | Cytoplasm and nucleus. Cytoplasmic and nuclear in the absence of TGF-beta; migrates to the nucleus when complexed with SMAD4 upon TGF-beta stimulation. Dephosphorylation by phosphatase PPM1A leads to release from SMAD2/SMAD4 complex and nuclear export via RANBP1. Mainly nuclear in early embryo development, later cytoplasmic at blastocyst and epiblast stages. |
Background
The protein encoded by this gene belongs to the SMAD family, homologous to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma genes. SMAD proteins are signal transducers and transcriptional modulators mediating multiple signaling pathways. Smad2 mediates TGF-beta signaling, regulating cell proliferation, apoptosis, and differentiation. It interacts with SARA protein and is phosphorylated by TGF-beta receptors, promoting dissociation from SARA and association with SMAD4, which is essential for nuclear translocation and transcriptional regulation.
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