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ELK Biotechnology Arrestin-β-1 (phospho Ser412) rabbit pAb
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Arrestin-β-1 (phospho Ser412) rabbit polyclonal antibody로, 인산화된 Ser412 부위를 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며, 인간 및 원숭이 시료에 반응합니다. 세포 내 위치 연구 및 GPCR 탈감작 연구에 적합합니다.
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- pk
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ELK Biotechnology ES6147-100UL Arrestin-β-1 (phospho Ser412) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES6147-50UL Arrestin-β-1 (phospho Ser412) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Arrestin-β-1 (phospho Ser412) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Arrestin-β-1 (phospho Ser412) rabbit pAb |
| Alternative Names | ARRB1; ARR1; Beta-arrestin-1; Arrestin beta-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412. AA range: 369-418 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 47 kD |
| Gene ID (Human) | 408 |
| Human Swiss-Prot No | P49407 |
| Species Reactivity | Human; Monkey |
| Cellular Localization | Cytoplasm, Nucleus, Cell membrane, Membrane (clathrin-coated pit), Cell projection (pseudopodium), Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus, the oligomeric form in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). |
| Background | Members of the arrestin/beta-arrestin protein family participate in agonist-mediated desensitization of G-protein-coupled receptors, dampening cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 acts as a cofactor in BARK-mediated desensitization of beta-adrenergic receptors. It is expressed at high levels in peripheral blood leukocytes and plays a major role in receptor-mediated immune regulation. Alternatively spliced transcripts encoding different isoforms have been described. [RefSeq, Jan 2011] |
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