ELK Biotechnology LRP1 rabbit pAb
LRP1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 CD91 유래 펩타이드로 면역화. 세포막 및 세포질에서 발현되는 LRP1 검출에 적합. -20°C에서 1년 보관 가능.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology LRP1 rabbit pAb
제품명
LRP1 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
LRP1은 저밀도 지단백 수용체(LDL receptor) 계열에 속하는 단백질로, 세포 내 신호전달, 지질 항상성, 및 아포토시스 세포 제거에 관여합니다. 본 항체는 인간 CD91 유래 펩타이드(AA 4486-4535)에 대한 토끼 폴리클로날 항체로, LRP1 검출에 활용됩니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | LRP1 rabbit pAb |
| Alternative Names | LRP1; A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CD91 (AA range: 4486–4535) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kD |
| GeneID (Human) | 4035 |
| Human Swiss-Prot No | Q07954 |
| Storage | -20°C / 1 year |
| Host Species | Rabbit |
세포 내 위치 (Cellular Localization)
- LRP1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein; Membrane, coated pit
- LRP1 515 kDa subunit: Cell membrane; Peripheral membrane protein; Extracellular side; Membrane, coated pit
- LRP1 intracellular domain (LRPICD): Cytoplasm, nucleus; After cleavage, detected both in cytoplasm and nucleus
- Golgi outpost: Cytoplasm, cytoskeleton, microtubule organizing center; Localizes to postsynaptic Golgi apparatus region (Golgi outpost), shaping dendrite morphology by acentrosomal microtubule nucleation sites
Background
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712).
This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells.
Additionally, it is necessary for alpha-2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients.
Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer’s disease patients.
[provided by RefSeq, Oct 2015]
제품 이미지
(이미지 없음)
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.