ELK Biotechnology Lamin A/C (phospho Ser392) rabbit pAb

제품명

Lamin A/C (phospho Ser392) rabbit pAb

제품 정보

세포 내 위치

Nucleus, nuclear envelope, nuclear lamina, nucleoplasm, and nucleus matrix.
Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group, producing mature lamin-A/C that integrates into the nuclear lamina.
EMD is required for proper localization of non-farnesylated prelamin-A/C.
Isoform C: localized in nucleus speckle.

배경 (Background)

Lamin A/C (LMNA) is a component of the nuclear lamina, a protein matrix adjacent to the inner nuclear membrane. Lamin proteins are evolutionarily conserved and play key roles in nuclear stability, chromatin organization, and gene expression.
During mitosis, lamins are phosphorylated, leading to reversible disassembly of the lamina. Vertebrate lamins are classified into A and B types, with LMNA encoding multiple transcript variants via alternative splicing.
Mutations in LMNA are associated with several diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb-girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
(RefSeq, Apr 2012)