ELK Biotechnology Lamin A/C (phospho Ser22) rabbit pAb

Lamin A/C (phospho Ser22) rabbit pAb

제품 정보

세포 내 위치 (Cellular Localization)

Nucleus, nuclear envelope, nuclear lamina, nucleoplasm, and nucleus matrix.
Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group, producing mature lamin-A/C that integrates into the nuclear lamina.
EMD is required for proper localization of non-farnesylated prelamin-A/C.
[Isoform C]: Nucleus speckle.

Background

Lamin A/C (LMNA) is a structural component of the nuclear lamina, forming a two-dimensional matrix adjacent to the inner nuclear membrane. Lamin proteins are evolutionarily conserved and play essential roles in nuclear stability, chromatin organization, and gene expression. During mitosis, lamin proteins are phosphorylated, leading to reversible disassembly of the lamina.
Vertebrate lamins are classified into A and B types, and alternative splicing produces multiple transcript variants.
Mutations in LMNA are associated with several diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb-girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
(RefSeq, Apr 2012)