ELK Biotechnology LIMK-2 (phospho Ser283) rabbit pAb
LIMK-2 (phospho Ser283) rabbit pAb는 인산화된 Ser283 부위를 인식하는 다클론 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 마우스, 랫, 원숭이에 반응하며 세포 골격 관련 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
LIMK-2 (phospho Ser283) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | LIMK2; LIM domain kinase 2; LIMK-2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LIMK2 around the phosphorylation site of Ser283. AA range: 249-298 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 72 kD |
| GeneID (Human) | 3985 |
| Human Swiss-Prot No | P53671 |
| Cellular Localization | Cytoplasm, cytoskeleton, spindle; cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Isoform LIMK2a: Cytoplasm, nucleus. Isoform LIMK2b: Cytoplasm, perinuclear region, nucleus. Mainly present in the cytoplasm and scarcely translocated to the nucleus. |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
There are approximately 40 known eukaryotic LIM proteins, named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing two zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif likely mediates protein–protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with two N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho. It phosphorylates cofilin, inhibiting its actin-depolymerizing activity, contributing to Rho-induced actin cytoskeleton reorganization. At least three transcript variants encoding different isoforms have been identified for this gene.
(Provided by RefSeq, Jul 2008)
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