ELK Biotechnology DNA Ligase IV rabbit pAb
DNA Ligase IV rabbit polyclonal antibody로, 인간·쥐·마우스 시료에 반응합니다. IHC, IF, WB, ELISA에 적합하며 DNA 수선 및 V(D)J 재조합 연구에 활용됩니다. 핵 내 단백질 검출에 유용하고 -20°C에서 1년간 보관 가능합니다.
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DNA Ligase IV rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | DNA Ligase IV rabbit pAb |
| Alternative Names | LIG4; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4 |
| Applications | IHC; IF; WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human DNA Ligase 4 (AA range: 616–665) |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 133 kD |
| Gene ID (Human) | 3981 |
| Human Swiss-Prot No | P49917 |
| Cellular Localization | Nucleus |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). It forms a complex with XRCC4 and interacts with DNA-PK, both required for NHEJ. The crystal structure of the XRCC4–DNA Ligase IV complex has been resolved. Defects in this gene cause LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
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