ELK Biotechnology DNA Ligase IV (phospho Thr650) rabbit pAb
DNA Ligase IV (phospho Thr650) rabbit pAb는 인산화된 Thr650 부위를 인식하는 항체로, IHC, IF, ELISA에 적합합니다. V(D)J 재조합 및 DNA 이중가닥 절단 복구 연구에 활용되며, 인간, 생쥐, 랫트 시료에 반응합니다. 핵 내 단백질 검출에 유용합니다.
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제품명
DNA Ligase IV (phospho Thr650) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | LIG4; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against a synthesized peptide derived from human DNA Ligase 4 around the phosphorylation site of Thr650. (AA range: 616–665) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 3981 |
| Human Swiss-Prot No. | P49917 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). It forms a complex with the X-ray repair cross complementing protein 4 (XRCC4) and interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene cause LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. (RefSeq, Jul 2008)
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